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肝癌微环境及其药物干预研究进展
作者: 崔 敏1,刘清华 来源:《转化医学电子杂志》 2017-12-01

  【Abstract】 Hepatocellular carcinoma (HCC) is one of the most common highly malignant tumors in the digestive system. Besides HCC cells, the microenvironment also plays a key role both in hepatocarcinogenesis and its development. Meanwhile, HCC microenvironment is the very place that hepatocarcinogenesis occurs, which consists of both cell components and non⁃cell components. Cell components include hepatic stellate cells (HSCs),tumor⁃associated fibroblasts (TAF), tumor⁃associated macrophages ( TAM), tumor⁃associated immune cells, regulatory T cells and tumor⁃associated endothelial cell (TEC), etc. While the non-cell components include extracellular matrix (ECM), extracellular matrix protein, enzymes, inflammatory factors, various cytokines and receptors, etc. These ingredients play an important regulatory role in the process of formation, proliferation, adhesion,migration and invasion of HCC cells. Recently, HCC microenvironment has been considered as a potential target for the cure of HCC. And the drug interventions nowadays mainly consist of antifibrosis agents, anti⁃tumor angiogenesis agents, and immune regulation agents, etc.

  【Keywords】 hepatocellular carcinoma; tumor microenvironment;pharmacological intervention

  【摘 要】 肝癌(HCC)是一种较常见且恶性程度较高的消化系统恶性肿瘤. 在 HCC 的发生、发展过程中,除了 HCC 细胞本身外,HCC 微环境发挥着至关重要的作用. HCC 微环境是HCC 在其发生过程中所处的内环境,它由细胞成分和非细胞成分共同构成. 细胞成分主要包括肝星状细胞、肿瘤相关成纤维细胞、肿瘤相关巨噬细胞、肿瘤相关免疫细胞、调节 T 细胞和肿瘤相关内皮细胞等;非细胞成分主要包括细胞外基质、胞外基质蛋白、酶类、炎症因子和细胞因子及其受体等. 这些成分在 HCC 细胞的形成、增殖、侵袭、迁移、黏附等过程中均发挥着重要的调控作用. 近年来,将 HCC 微环境作为潜在作用靶点已成为研究 HCC 癌前状态和肝细胞癌药物治疗的新方向和热点领域. 目前,干预 HCC 微环境的药物主要包括抗纤维化、抗肿瘤血管生成和免疫调节药物等.

  【关键词】 肝细胞癌;肿瘤微环境;药物干预

  【中图分类号】 R735.7 【文献标识码】

  阅读原文:www.ejotm.com/ch/reader/view_abstract.aspx