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好文推荐:STAT3、STAT5在NK细胞中的抗肿瘤作用研究进展
作者:于淮海 来源:滨州医学院 2017-05-22

中文摘要:

  NK细胞构成机体抗肿瘤的第一道防线,STAT通路在其中发挥着重要的作用。无论是对肿瘤细胞的生长、对肿瘤细胞的杀伤还是机体免疫细胞的相互调节,STAT通路均活跃参与其中。其中抑制STAT3或激活STAT5都能增强NK细胞对肿瘤细胞的杀伤作用。STAT3与STAT5亦存在互相调节,影响多种细胞的生物功能,但在NK细胞中的研究较少。通过对近几年关于STAT3和STAT5在NK细胞中的抗肿瘤作用的调研,本文旨在为促进NK细胞在抗肿瘤中的应用提供理论依据。

  英文摘要:

  NK cells constitute the first line of defense against cancer, STAT pathway plays an important role in it. STATs are actively involved in tumor cell growth, cytotoxicity of NK cells on tumor cells and regulation of immune cells. STAT3 and STAT5 are also regulated by each other, but few studies have been done on NK cells. In this paper, we reviewed the recent progress in the research of STAT3 and STAT5 in the antitumor effects of NK cells. The study of its mechanism will be helpful for us to make better use of STATs in anti-tumor therapy.

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http://www.ejotm.com/ch/reader/create_pdf.aspx?file_no=20170405001&flag=&journal_id=zhyxdzzz&year_id=2017