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好文推荐:循环肿瘤细胞与肿瘤转移机制的研究进展
作者:林健,李恒宇 ,吴凯男等 来源:第二军医大学附属长海医院 2017-05-22

  中文摘要:

  转移是肿瘤引起死亡的主要原因,循环肿瘤细胞(circulating tumor cells,CTCs)与肿瘤转移密切相关。本文通过已有的文献,回顾分析有关循环肿瘤细胞一系列转移过程:迁移渗入血液循环系统、适应外周循环系统并渗出至远端器官、突破免疫防御形成转移灶,了解其中涉及的可能影响肿瘤转移的诸多因素,例如毛细血管壁构成、组织微环境、细胞因子调节、细胞间相互作用、信号通路调节等。通过这些文献的复习,帮助我们进一步了解肿瘤转移相关机制。

  英文摘要:

  Metastasis is the main cause of tumor death, circulating tumor cells (CTCs) are closely related to tumor metastasis. In this paper, a series of metastatic processes of CTCs were reviewed and analyzed: migrating into the circulating system, adapting to peripheral circulatory system, penetrating to distant organs, breaking through the immune defense and forming metastases. From the content mentioned above, we understand the factors that may affect tumor metastasis including constitution of blood capillary wall, metastatic organ niche, cytokine modulation, mutual interaction between cells, regulation of signal pathways and through which might help us understand some mechanisms of tumor metastasis.

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http://www.ejotm.com/ch/reader/create_pdf.aspx?file_no=20170208002&flag=&journal_id=zhyxdzzz&year_id=2017